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bronchitis asthma

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By Targets:	Adenosine Receptor (1) Adrenergic Receptor (3) Antibiotic (1) Bacterial (1) CCR (1) Cholinesterase (ChE) (1) Cytochrome P450 (1) Monoamine Oxidase (1) P2Y Receptor (1) Parasite (1) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (1) TRP Channel (1)
By Research Areas:	Endocrinology (3) Infection (5) Inflammation/Immunology (12) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

15

Inhibitors & Agonists

3

Natural
Products

1

Isotope-Labeled Compounds

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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

PIT 2,2'-Pyridylisatogen tosylate	P2Y Receptor	Inflammation/Immunology
PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC₅₀ value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma .

GW 766994 2 Publications Verification GW 994	CCR	Inflammation/Immunology Endocrinology
GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research .

Hexoprenaline	Adrenergic Receptor	Infection Inflammation/Immunology
Hexoprenaline is an orally active and selective β-adrenergic receptor agonist that dilates the bronchi. Hexoprenaline can be used in the study of bronchospasm, including asthma, bronchitis, and emphysema .

Shinjulactone M	Parasite	Infection Neurological Disease Inflammation/Immunology
Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma .

HY-100250

Spirofylline

Others Inflammation/Immunology

Spirofylline is a bronchodilator that has the potential for asthma and bronchitis and emphysema treatment.

Fenoterol Th-1165; Phenoterol
Fenoterol (Th-1165), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .

Fenoterol hydrobromide Th-1165a; Phenoterol hydrobromide
Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .

Isoetharine hydrochloride Isoetarine hydrochloride	Others	Infection
Isoetharine hydrochloride is selective, short-acting and orally active β-agonist which is widely used as a bronchodilator in the research of inhalation research .

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate	Cytochrome P450 Monoamine Oxidase	Inflammation/Immunology
8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC₅₀s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC₅₀s of 60.2 and 38.6 μM, respectively .

Fenoterol hydrobromide (Standard) Th-1165a (Standard); Phenoterol hydrobromide (Standard)	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Fenoterol (hydrobromide) (Standard) is the analytical standard of Fenoterol (hydrobromide). This product is intended for research and analytical applications. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research .

Telithromycin 5 Publications Verification HMR3647; RU66647	Bacterial Antibiotic	Infection Inflammation/Immunology
Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma .

Fenoterol-d6 hydrobromide	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Fenoterol-d₆ (hydrobromide) (Th-1165a-d6) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

Doxofylline	Adenosine Receptor Phosphodiesterase (PDE) Reactive Oxygen Species	Inflammation/Immunology
Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm .

Nodakenin	Cholinesterase (ChE)	Inflammation/Immunology
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

IA-Alkyne Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide	TRP Channel	Infection Inflammation/Immunology
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Category	Target	Chemical Structure

Nodakenin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Inflammation/Immunology Disease Research Fields Chelonopsis giraldii Diels	Cholinesterase (ChE)
Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC₅₀ of 84.7 μM .

Shinjulactone M	Infection Simaroubaceae Ailanthus altissima (Mill.) Swingle Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields	Parasite
Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma .

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Cytochrome P450 Monoamine Oxidase
8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC₅₀s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC₅₀s of 60.2 and 38.6 μM, respectively .

Cat. No.	Product Name	Chemical Structure

Fenoterol-d6 hydrobromide
Fenoterol-d₆ (hydrobromide) (Th-1165a-d6) is the deuterium labeled Fenoterol hydrobromide. Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research[1][2].

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